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Radiographic and Histologic Study After Infusion of Contrast Media into Rabbit Submandibular Gland

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Abstract

°¡ÅäÀÇ ¾ÇÇϼ± 50°³¿¡ »ý¸®½Ä¿°¼ö ¹× 5Á¾·ùÀÇ ¹æ»ç¼± Á¶¿µÁ¦¸¦ Á¤»ó¿ë·®°ú °ú¿ë·® ÁÖÀÔÇÑ
ÈÄ ¹æ»ç¼±ÇÐÀû ¹× Á¶Á÷ÇÐÀûÀ¸·Î °üÂûÇÏ¿© ´ÙÀ½°ú °°Àº °á·ÐÀ» ¾ò¾ú´Ù.
1. »ç¿ëÇÑ ¸ðµç ¼ö¿ë¼º Á¶¿µÁ¦´Â ¼­·Î À¯»çÇÑ ¹æ»ç¼±»çÁø»ó ¹Ðµµ¸¦ º¸¿´À¸¸ç Á¤»ó ¹× °ú
ÁÖÀÔÀÇ °æ¿ì¿¡ 5ºÐÁ¤µµÈÄ¿¡ Èí¼öµÇ¾úÀ¸³ª Telebrix 30Àº ÁÖÀÔÈÄ 30ºÐ±îÁö ¼Ò·®ÀÌ ÀÜÁ¸ÇÏ¿´
´Ù.
2. Áö¿ë¼º Á¶¿µÁ¦ Lipiodol UF´Â ¿ì¼öÇÑ ¹æ»ç¼±»çÁø»ó ¹Ðµµ¸¦ º¸¿´À¸¸ç Åõ¿©ÈÄ 24½Ã°£¿¡
µµ ÀÜÁ¸»óÀÌ °üÂûµÇ¾ú´Ù.
3. »ý¸®½Ä¿°¼ö¸¦ ÁÖÀÔÇÑ Å¸¾×¼±¿¡ À־´Â ÁÖÀÔÁ÷ÈÄ¿¡ ¹Ì¾àÇÑ °üÈ®À常À» °üÂûÇÒ ¼ö ÀÖ
¾ú´Ù.
4. Telebrix 30Àº ÁÖÀÔÁï½Ã ¹× 24½Ã°£ÈÄ¿¡ »ó´çÇÑ Á¤µµÀÇ °üÈ®Àå°ú ¿°Áõ¼Ò°ßÀÌ °üÂûµÇ¾ú
À¸¸ç ÀÌ°ÍÀº °ú·®ÁÖÀԽà ´õ¿í ½ÉÇÏ¿´´Ù. 7ÀÏ¿¡´Â Ÿ¾×¼±ÀÇ »ó´çÇÑ ¼¶À¯Áõ½Ä »óÀÌ °üÂûµÇ¾ú
°í °ú·®ÁÖÀÔÇÑ °æ¿ì ºÎºÐÀûÀÎ Á¶Á÷±«»ç°¡ °üÂûµÇ¾ú´Ù.
5. Hypaque 60%¸¦ ÁÖÀÔÇÑ °æ¿ì Telebrix 30À» ÁÖÀÔÇßÀ» ¶§¿Í À¯»çÇÑ Á¶Á÷º¯È­¸¦ º¸¿´À¸
³ª ÁÖÀÔ 7ÀÏÈÄ¿¡ Á»´õ ½ÉÇÑ Á¶Á÷Æı«°¡ °üÂûµÇ¾ú´Ù.
6. Urografin 60%´Â º»¿¬±¸¿¡¼­ »ç¿ëÇÑ Á¶¿µÁ¦ Áß¿¡¼­ °¡Àå ¹Ì¾àÇÑ Á¶Á÷º¯È­¸¦ º¸¿´´Ù.
7. Biliscopin ÁÖÀԽô ¾àÇÑ °üÈ®ÀåÀÌ º¸ÀÌ´Ù°¡ Á¤»ó¿ë·® ÁÖÀÔ ÀÎ °æ¿ì 7ÀÏÈÄ¿¡´Â Á¤»óÅ©
±â·Î µ¹¾Æ¿À´Â ¼Ò°ßÀ» º¸¿´À¸³ª À̶§ »ó´çÇÑ ¿°Áõ¹ÝÀÀ°ú Á¶Á÷±«»çºÎÀ§°¡ °üÂûµÇ¾ú´Ù.
8. Lipiodol UF´Â ´Ù¼öÀÇ Á¶¿µÁ¦¾×Æ÷¿Í ÇÔ²² ½ÉÇÑ °üÈ®ÀåÀ» º¸¿´À¸¸ç ÁÖÀÔÈÄ 7ÀÏ¿¡´Â Á¶
Á÷¼¶À¯Áõ½Ä»óÀ» º¸¿´À¸³ª Á¶Á÷±«»çºÎÀ§´Â °üÂûµÇÁö ¾Ê¾Ò´Ù.
#ÃÊ·Ï#
50 submandibular glands of rabbits were examined historadiologically after infusion
with normal and over volumes of physiologic saline and 5 radiographic contrast media.
The results were as follows:
1. All water soluble contrast media showed similar radiographic contrasts and
absorbed about 5 minutes after infusion except Telebrix 30 which took 30 minutes in
both normal and overfilled glands.
2. Lipid soluble medium, Lipiodol UF had excellent radiographic contrast and could be
seen on the radiograms even after 24 hours after infusion.
3. Salivary glands infused with physiologic saline didn't show any histologic changes
except slight duct dilation right after infusion.
4. Telebrix 30 caused mild to moderate duct dilation and inflammation at immediate &
24 hours after infusion which was more severe in overfilled glands. At 7 days after
infusion, there were mild to moderate fibrosis of the gland and areas of necrosis was
seen in overfilled glands.
5. Hypaque, 60% showed similar histologic reactions to Telebrix 30 except more
severe tissue destruction at 7 days after infusion.
6. Urografin 60% showed mildest histologic changes among the media used in the
study.
7. Biliscopin had mild duct dilation which returned to normal after 7 days but there
were moderate inflammation and tissue necrosis at that time.
8. Lipiodol UF showed severe duct dilation with numerous vacuoles arid there were
tissue fibrosis at 7 days after infusion but no tissue necrosis was seen.

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